NeuroMab™ Anti-Ankyrin-R BBB Shuttle Antibody, Clone N388A/10

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ANK1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R (also known as Ankyrin-1, Erythrocyte Ankyrin, ANK-1, ANK and rCG_43073, accession number P16157)
Mouse: 90% identity (1678/1858 amino acids identical)
Rat: 74% identity (1329/1788 amino acids identical)
>50% identity with Ankyrin-B and Ankyrin-G

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N388A/10

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Ankyrin-B or Ankyrin-G

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ANK1

Official Name

ANK1

Full Name

Ankyrin-R

Alternative Names

ANK1; Ankyrin-R

Uniprot ID

P16157

Product Pictures

Fig. 1 Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Ankyrin-R knockout (KO) mouse brains probed with N388A/10 (left) and K58/35 (right) TC supe.