NeuroMab™ Mouse Anti-Rat GluN2B/NMDAR2B Monoclonal Antibody (CBP2368)
[CAT#: NAB2010375LS]
Anti-GluN2B/NMDAR2B Monoclonal Antibody [HRP]
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- WB
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Glutamate activated Ion channels that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDA receptor plays an essential role in the induction of LTP in the CA1 and dentate areas of the hippocampus as the specific NMDA antagonist, APV blocks LTP in these areas. This receptor has also been linked to neuronal development and it has been implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.
Immunogen
A fusion protein corresponding to amino acids 20-271 (extracellular, N-terminus) of rat GluN2B/NR2B glutamate receptor protein.
Species Reactivity
Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2a
Clone Number
CBP2368
Applications
WB
Application Notes
WB (0.2-0.5 µg/mL); IHC (10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Product Properties
Form
Liquid
Formulation
This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Handling Advice
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
GRIN2B
Official Name
GRIN2B
Full Name
Glutamate [NMDA] receptor subunit epsilon-2
Alternative Names
GRIN2B; GluN2B; MRD6; NMDAR2B; NR2B; hNR3; EIEE27; glutamate ionotropic receptor NMDA type subunit 2B; NR3
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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