NeuroMab™ Mouse Anti-PTPRC Monoclonal Antibody (CBP2678)

Product Overview

Description

CD45 is a type I transmembrane protein expressed on the surface of all haematopoietic cells with the exception of erythrocytes and platelets (PMID: 3489673; 28615666). CD45 is a pan-haematopoietic cell marker and has been shown to be essential for T- and B-cell activation and signalling (PMID: 9429890; 16378097). CD45 exists as multiple isoforms due to alternative splicing of three exons (4, 5, and 6, designated A, B, and C) in the extracellular domain (PMID: 12414720). CD45RO is the shortest CD45 isoform (lacking all three exons) and is expressed by activated and memory T cells, thymocytes, some B cells, and weakly on granulocytes and macrophage.

Expression Host

Mammalian cells

Immunogen

IL-2 dependent T cell line, CA1

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2678

Applications

FC; ELISA

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1888

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

500 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD45

Official Name

PTPRC

Full Name

Protein tyrosine phosphatase, receptor type, C

Alternative Names

B220; CD45; CD45R; GP180; L CA; LCA; Leukocyte common antigen; LY5; PTPRC; RPTPC; T200

Gene ID

5788(Human)

Uniprot ID

P08575(Human)

References

1. Li, Q., Zhai, Y., Man, X., Zhang, S., & An, X. (2020). Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells. Cellular Reprogramming, 22(2), 82-89. 2. Matsunari, H., Watanabe, M., Hasegawa, K., Uchikura, A., Nakano, K., Umeyama, K.,... & Nishinakamura, R. (2020). Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation. Stem cell reports, 14(1), 21-33.

Publications