Mouse Anti-ATRX Monoclonal Antibody (CBP6757)

Description

Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6757

Applications

IHC; WB; IF

Application Notes

IHC: 1:200-1:500
WB: 1 µg/ml
IF: 2-10 µg/ml

Relevant Diseases

Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

ATRX

Official Name

ATRX

Full Name

ATRX, Chromatin Remodeler

Alternative Names

ATRX, Chromatin Remodeler; ATP-Dependent Helicase ATRX; X-Linked Nuclear Protein; X-Linked Helicase II; ZNF-HX; RAD54L; XH2; XNP; Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 (S. Cerevisiae) Homolog); Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 Homolog, S. Cerevisiae); Alpha Thalassemia/Mental Retardation Syndrome X-Linked

Gene ID

546(Human); 22589(Mouse); 246284(Rat)

Uniprot ID

P46100(Human); Q61687(Mouse); P70486(Rat)