Mouse Anti-NET Monoclonal Antibody (CBP6805)

Description

Synaptic signaling is the communication between cells that occurs at the synaptic level. Cells communicate with each other through direct contact (near secretory signals), short distances (paracrine signals), or long distances and scales (endocrine signals). Other cells form gap junctions, connecting their cytoplasm to The cytoplasm of adjacent cells. When the sending neuron is activated, the electrical impulse will propagate with it Axon. Once the impulse reaches the synapse, it triggers the release of neurotransmitters. Norepinephrine transporter (NET), also known as norepinephrine transporter (NAT) and solute carrier family 6 member 2 (SLC6A2), is a protein encoded by the SLC6A2 gene in humans. NET is a monoamine transporter responsible for sodium chloride (Na + /Cl-)-dependent reuptake of extracellular norepinephrine (NE) (also known as norepinephrine). NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential for regulating the concentration in the synaptic space. Together with other monoamine transporters, NET has become the target of many antidepressants and recreational drugs. In addition, ADHD is related to ADHD. There is evidence that the single nucleotide polymorphism in the NET gene (SLC6A2) may be a potential factor for some of these diseases.

Epitope

Binds to an located within the peptide sequence HTKYSKYKFTPAAEF

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6805

Applications

IHC

Application Notes

IHC: 1:200-1:500

Research Areas

Neurotransmitter

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

Noradrenaline Transporter

Official Name

NET

Full Name

Noradrenaline transporter

Alternative Names

SLC6A2; NAT1; NET; NET1; SLC6A5; solute carrier family 6 member 2; Norepinephrine transporter; norepinephrine transporter gene

Gene ID

6530(Human); 20538(Mouse); 83511(Rat)

Uniprot ID

P23975(Human); O55192(Mouse)