Mouse Anti-ITGA4 Monoclonal Antibody (CBP6847)

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. CD49d is the integrin alpha subunit. It constitutes half of the homing receptors of α4β1 lymphocytes.The product of this gene belongs to the integrin alpha chain protein family. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. This gene encodes the α4 chain. Unlike other integrin α chains, α4 contains neither an I domain nor undergoes disulfide bond cleavage. The Alpha 4 chain is associated with the beta 1 chain or beta 7 chain.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6847

Applications

WB

Application Notes

WB: 1 µg/ml

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

ITGA4

Official Name

ITGA4

Full Name

Integrin alpha 4

Alternative Names

ITGA4; CD49D; IA4; integrin subunit alpha 4

Gene ID

3676(Human); 16401(Mouse)

Uniprot ID

P13612(Human); Q00651(Mouse)