NeuroMab™ Anti-Amyloid Beta 1-40 BBB Shuttle Antibody(NRZP-1022-ZP3658)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

In Vitro; ELISA; Antagonist

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

AmyloidBeta1-40

Official Name

Amyloid Beta

Full Name

Amyloid Beta

Alternative Names

APP; Aβ; Abeta; Amyloid β

Product Pictures

ELISA

Figure 12 shows the epitope mapping of antibodies 2294 and 6G by ELISA.

Various A13 peptides were immobilized on ELISA plates. Antibodies were incubated with various immobilized peptides for 1 hour. Antibody 6G bound to immobilized A (measured with 3 peptides using goat anti-human kappa HRP-conjugated secondary antibody). Antibody 2294 bound to immobilized A (measured with goat anti-mouse antibody bound to heavy and light chains 3 peptides and are HRP-conjugated secondary antibodies. "NB" means no binding detected. Numbers in the column under "2294" and "6G" indicate absorbance at 450nm.

Publications