NeuroMab™ Anti-Clcn3 BBB Shuttle Antibody, Clone N258/5

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CLC3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 98-115 (CKDRERHRRINSKKKESA, cytoplasmic N-terminus) of human Clcn3 (also known as H(+)/Cl(-) exchange transporter 3, Chloride transporter ClC-3, Chloride channel protein 3 and Clc3, accession number P51790)
Mouse: 100% identity (18/18 amino acids identical)
Rat: 100% identity (18/18 amino acids identical)
<70% identity with Clcn4 and Clcn5

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N258/5

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Clcn4 or Clcn5 (based on KO validation results)

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CLC3

Official Name

CLCN3

Full Name

Clcn3

Alternative Names

CLCN3; CLC3; ClC-3; chloride voltage-gated channel 3

Uniprot ID

P51790

Product Pictures

Fig. 1 Immunoblot versus crude membranes from adult rat brain (RBM) and WT and Clcn3 KO mouse brains probed with N258/5 (left) and N52A/42 (right) TC supe.