NeuroMab™ Anti-Clcn3 BBB Shuttle Antibody, Clone N258/5
[CAT#: NRZP-0423-ZP76]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CLC3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Synthetic peptide amino acids 98-115 (CKDRERHRRINSKKKESA, cytoplasmic N-terminus) of human Clcn3 (also known as H(+)/Cl(-) exchange transporter 3, Chloride transporter ClC-3, Chloride channel protein 3 and Clc3, accession number P51790)
Mouse: 100% identity (18/18 amino acids identical)
Rat: 100% identity (18/18 amino acids identical)
<70% identity with Clcn4 and Clcn5
Mouse: 100% identity (18/18 amino acids identical)
Rat: 100% identity (18/18 amino acids identical)
<70% identity with Clcn4 and Clcn5
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N258/5
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Clcn4 or Clcn5 (based on KO validation results)
Research Areas
Ion channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
CLC3
Official Name
CLCN3
Full Name
Clcn3
Alternative Names
CLCN3; CLC3; ClC-3; chloride voltage-gated channel 3
Uniprot ID
P51790
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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