NeuroMab™ Anti-Clcn5 BBB Shuttle Antibody, Clone N406/47
[CAT#: NRZP-0423-ZP78]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ClC-5 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 568-746 (C-terminus) of rat Clcn5 (also known as H(+)/Cl(-) exchange transporter 5, Chloride channel protein 5, Chloride transporter ClC-5, Clc5 and CLCK2, accession number P51796)
Mouse: 99% identity (178/179 amino acids identical)
Human: 98% identity (177/179 amino acids identical)
>70% identity with Clcn3 and Clcn4
Mouse: 99% identity (178/179 amino acids identical)
Human: 98% identity (177/179 amino acids identical)
>70% identity with Clcn3 and Clcn4
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N406/47
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Clcn4
Research Areas
Ion channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
ClC-5
Official Name
CLCN5
Full Name
Clcn5
Alternative Names
CLCN5; CLC5; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; XLRH; XRN; hCIC-K2; chloride voltage-gated channel 5
Uniprot ID
P51796
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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