NeuroMab™ Anti-GAD67 BBB Shuttle Antibody, Clone L127/8

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GAD1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-594 (full-length) of human GAD67 (also known as Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD and DCE1, accession number Q99259)
Mouse: 97% identity (577/594 amino acids identical)
Rat: 97% identity (577/594 amino acids identical)
100% identity (213/213 amino acids identical) with GAD25
>90% identity (366/391 amino acids identical, highest in N-terminus) with GAD44
>60% identity (375/569 amino acids identical, highest in C-terminus) with GAD2/GAD65/DCE2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

L127/8

Applications

WB; IHC; ICC

Application Notes

Cross-reacts with GAD25;Does not cross-react with GAD44 or GAD65/GAD2

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GAD1

Official Name

GAD1

Full Name

GAD67

Alternative Names

Glutamate Decarboxylase 1; Glutamate Decarboxylase 1 (Brain; 67kDa); Glutamate Decarboxylase 67 KDa Isoform; 7 KDa Glutamic Acid Decarboxylase; EC 4.1.1.15; GAD-67; GAD;

Uniprot ID

Q99259

Product Pictures

Fig. 1 Array tomography immunofluorescence of an Lowicrylembedded 70 nm section from adult mouse neocortex with L127/8 (green), guinea pig polyclonal GABA (Millipore AB175, magenta) and DAPI (blue).

Publications