Tel:
Fax:
Email:
Creative Biolabs

NeuroMab™ Anti-GluN2A/NR2A glutamate receptor BBB Shuttle Antibody, Clone N327/95

[CAT#: NRZP-0423-ZP149]

Species Reactivity:
Rat; Mouse; Human
Applications:
WB; IHC; ICC

Datasheet MSDS Request COA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry

SPECIFIC INQUIRY

inquiry
Size:
Conjugation:
Endotoxin:
Purity:
Engineering:
Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GRIN2A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A (also known as Glutamate [NMDA] receptor subunit epsilon-1, N-methyl Daspartate receptor subtype 2A, Grin2a, NMDAR2A, accession number Q00959)
Mouse: 99% identity (250/251 amino acids identical)
Human: 97% identity (245/252 amino acids identical)
>60% identity with NR2B

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N327/95

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with NR2B

Conjugation

Unconjugated
Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.
Target

Target

GRIN2A

Official Name

GRIN2A

Full Name

GluN2A/NR2A glutamate receptor

Alternative Names

GRIN2A; EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A; glutamate ionotropic receptor NMDA type subunit 2A

Uniprot ID

Q00959
Product Pictures
IB

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged NR2A, NR2B or untagged Kv2.1 plasmid and probed with N327/95 (left) and N86/38 (right) TC supe.

IHC

Fig. 2 Adult rat hippocampus immunohistochemstry.

IB

Fig. 3 Adult rat brain membrane immunoblot.

Publications

Publications (0)

gift-card

Related Products
For Research Use Only. Not For Clinical Use.
Product
Hot Products
Fill out this form for a quote Inquiry Form Send Inquiry
webinar

The Spectrum of Stem Cell-Based Neuronal Models and Their Fit for Purpose

2:00 PM–3:00 PM EST, December 12, 2024

REGISTER NOW
Inquiry Basket
compare

Send inquiry