NeuroMab™ Anti-NR2A glutamate receptor BBB Shuttle Antibody, Clone N327A/38
[CAT#: NRZP-0423-ZP148]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GRIN2A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 75-325 (extracellular N-terminus) of rat NR2A (also known as Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, Grin2a, NMDAR2A, accession number Q00959)
Mouse: 99% identity (250/251 amino acids identical)
Human: 97% identity (245/252 amino acids identical)
>60% identity with NR2B
Mouse: 99% identity (250/251 amino acids identical)
Human: 97% identity (245/252 amino acids identical)
>60% identity with NR2B
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
N327A/38
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with NR2B
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GRIN2A
Official Name
GRIN2A
Full Name
GluN2A/NR2A glutamate receptor
Alternative Names
GRIN2A; EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A; glutamate ionotropic receptor NMDA type subunit 2A
Uniprot ID
Q00959
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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