NeuroMab™ Anti-NR2A glutamate receptor BBB Shuttle Antibody, Clone N327A/38

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GRIN2A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat NR2A (also known as Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, Grin2a, NMDAR2A, accession number Q00959)
Mouse: 99% identity (250/251 amino acids identical)
Human: 97% identity (245/252 amino acids identical)
>60% identity with NR2B

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N327A/38

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with NR2B

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GRIN2A

Official Name

GRIN2A

Full Name

GluN2A/NR2A glutamate receptor

Alternative Names

GRIN2A; EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A; glutamate ionotropic receptor NMDA type subunit 2A

Uniprot ID

Q00959

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged NR2A, NR2B or untagged Kv2.1 plasmid and probed with N327A/38 (left) and N86/38 (right) TC supe.

Publications