NeuroMab™ Anti-KChIP3 potassium channel BBB Shuttle Antibody, Clone K66/38

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNIP3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-256 (full-length) of rat KChIP3 (also known as Kv channel-interacting protein 3, Kcnip3, A-type potassium channel modulatory protein 3, Calsenilin, Csen, DREantagonist modulator and Dream, accession number Q9JM47)
Mouse: 98% identity (251/256 amino acids identical)
Human: 93% identity (239/256 amino acids identical)
>50% identity with KChIP1, KChIP2 and KChIP4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

K66/38

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with KChIP1, KChIP2 or KChIP4

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNIP3

Official Name

KCNIP3

Full Name

KChIP3 K+ channel

Alternative Names

KCNIP3; CSEN; DREAM; KCHIP3; potassium voltage-gated channel interacting protein 3

Uniprot ID

Q9JM47

Product Pictures

Fig. 1 Immunoblot versus crude membranes from adult rat brain (RBM) and WT and KChIP3 KO mouse brains probed with K66/38 (left) and K55/82 (right) TC supe.