NeuroMab™ Anti-MMP9 metalloproteinase BBB Shuttle Antibody, Clone L51/82

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-MMP-9 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-708 (full-length) of rat MMP9 also known as matrix metalloproteinase 9, 92 kDa type IV collagenase, 92 kDa gelatinase, gelatinase B and GELB, accession number NP_112317)
Human: 68% identity (482/708 amino acids identical)
Mouse: 74% identity (548/731 amino acids identical)
<50% identity with MMP2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

L51/82

Applications

WB; IHC; IP; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

MMP-9

Official Name

MMP9

Full Name

MMP9

Alternative Names

MMP9; CLG4B; GELB; MANDP2; MMP-9; 92 kDa type IV collagenase; 92 kDa gelatinase; gelatinase B; matrix metallopeptidase 9

Uniprot ID

NP_112317

Product Pictures

Fig. 1 Immunoblot versus lysates of whole rat brain (WBH) and of COS-1 cells transfected with human and rat MMP9 (hMMP9 and rMMP9, respectively) and Kv2.1 plasmids and probed with L51/82 (left), K89/34 (middle) and loading control (right) TC supe.