NeuroMab™ Anti-MMP9 BBB Shuttle Antibody(NRZP-1022-ZP3192)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse; Chimeric

Applications

ELISA; IHC; In Vitro; In Vivo

Relevant Diseases

Epilepsy; Multiple Sclerosis; Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

MMP-9

Official Name

MMP9

Full Name

Matrix metalloproteinase-9

Alternative Names

MMP9; CLG4B; GELB; MANDP2; MMP-9; 92 kDa type IV collagenase; 92 kDa gelatinase; gelatinase B; matrix metallopeptidase 9

Product Pictures

IHC

Figure 1 shows immunohistochemistry (IHC) performed on serial sections of frozen colon from vehicle-treated mice (A) and AB0046-treated mice (B).

FuncS

Figure 2 is a graph showing the results of endoscopic evaluations performed on all animal groups on days 10 and 14 (end date).

The figure shows the average endoscopy score (+/− SEM) from day 6 to day 14 and the arrow indicates the day of AB0046 administration (or other treatment).

IHC

Figure 3 shows representative Figures of MMP9 IHC of colon FFPE sections from the study

FuncS

Figure 4 is a graph showing the results of clinical scores and lower extremity scores.

This is a graph showing the clinical and lower limb scores resulting from the study described in Example 7. The efficacy of mouse surrogate anti-MMP9 antibody (AB0046) and anti-human MMP9 antibody (AB0041) in the mouse CIA model of rheumatoid arthritis and the rat CIA model has been shown. MTX = methotrexate; Non Dis. = Non-disease.

Publications