Mouse Anti-Human MMP-9 Monoclonal Antibody (CBP3873)

[CAT#: NAB2012427LS]

Anti-MMP-9 Monoclonal Antibody [Biotin]

Host Species:: Mouse

Species Reactivity:: Human

Applications:: ELISA

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Product Overview

Description

MMP9, or MMP-9, is a member of the matrix metalloprotease family of proteins (MMPs). MMP9 consists of a prodomain, catalytic domain, hinge region, and a hemopexin domain. It is secreted as an inactive zymogen that becomes activated extracellularly. The most relevant natural activators of proMMP9 are unknown. MMP9 activation may be mediated by removal of the prodomain by serine proteases or other MMPs, or it may be a direct response to oxidative stress that disrupts the cysteine switch. MMP9 is capable of processing cytokines and chemokines.

Immunogen

Recombinant Human MMP-9

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP3873

Applications

ELISA

Application Notes

ELISA (0.25 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

MMP-9

Official Name

MMP9

Full Name

Matrix metalloproteinase-9

Alternative Names

MMP9; CLG4B; GELB; MANDP2; MMP-9; 92 kDa type IV collagenase; 92 kDa gelatinase; gelatinase B; matrix metallopeptidase 9

Gene ID

4318 (Human); 17395 (Mouse)

Uniprot ID

P14780 (Human); P41245 (Mouse)

References

1. Chakrabarti S, Patel KD. 2005. Exp. Lung Res. 31:599.
2. Klein T, Bischoff R. 2011. Amino Acids. 41:271.
3. Raffetto JD, Khalil RA. 2008. Biochem. Pharmacol. 75:346.

Publications