NeuroMab™ Anti-Nav1.7 BBB Shuttle Antibody(NRZP-1022-ZP2482)
[CAT#: NRZP-1022-ZP2482]
- Host Species:
- Rabbit
- Species Reactivity:
- Human; Mouse
- Applications:
- ELISA; Block; Inhib; In Vivo; In Vitro
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Immunogen
The antibody binds to Human and Mouse domain B.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Host Species
Rabbit
Applications
ELISA; Block; Inhib; In Vivo; In Vitro
Relevant Diseases
Pain; Epilepsy
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
SCN9A
Official Name
SCN9A
Full Name
sodium voltage-gated channel alpha subunit 9
Alternative Names
SCN9A; ETHA; FEB3B; GEFSP7; HSAN2D; NE-NA; NENA; Nav1.7; PN1; SFNP; sodium voltage-gated channel alpha subunit 9
Product Pictures
ELISA
Fig.1 shows that the 932 and 983 anti-Nav1.7 monoclonal antibodies reduce electrically induced DRG spike frequency in vitro.
983 monoclonal antibody produces a dose-dependent inhibition of Nav1.7 currents.
ELISA
Fig.2 shows that anti-Nav1.7 monoclonal antibody 932 reduces electrically induced DRG spike frequency in vitro.
983 monoclonal antibody produces a dose-dependent inhibition of Nav1.7 currents.
ELISA
Fig.3 shows serum concentration-time profile for antibody 932 in male Sprague Dawley rats following a single 10 mg/kg sub-cutaneous dose.
983 monoclonal antibody produces a dose-dependent inhibition of Nav1.7 currents.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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