NeuroMab™ Anti-Neuroligin-3 BBB Shuttle Antibody, Clone N110/29

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Neuroligin 3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 730-848 (intracellular C-terminus) of rat Neuroligin-3 (also known as gliotactin homolog, accession number AAA97871)
Mouse: 99% identity (118/119 amino acids identical)
Human: 98% identity (116/119 amino acids identical)
~60% identity with Neuroligin-1 ~40% identity with Neuroligin-2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N110/29

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Neuroligin-1, -2, -4 or -4*

Research Areas

CAMs

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Neuroligin 3

Official Name

NLGN3

Full Name

Neuroligin-3

Alternative Names

NLGN3; HNL3; neuroligin 3

Uniprot ID

AAA97871

Product Pictures

Fig. 1 Adult mouse brain immunoblot: extracts of brains from Neuroligin-3 wild-type (WT) and knockout (KO) mice were probed with N110/29 TC supe.

Fig. 2 Adult mouse brain membrane (MBM) and transfected cell immunoblot: extracts of MBM and COS cells transiently transfected with Neuroligin-1, -2, -3, -4 and -4* plasmids and probed with N110/29 TC supe.