NeuroMab™ Anti-Slc18a2/VMAT2 BBB Shuttle Antibody, Clone N449/73
[CAT#: NRZP-0423-ZP469]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VMAT2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 42-132 (first lumenal domain) of mouse Slc18a2 (also known as Synaptic vesicular amine transporter, Monoamine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2, Svmt, Svat and Vmat2, accession number Q66L40)
Rat: 82% identity (75/92 amino acids identical)
Human: 73% identity (67/92 amino acids identical)
<30% identity with Slc18a1/VMAT1
Rat: 82% identity (75/92 amino acids identical)
Human: 73% identity (67/92 amino acids identical)
<30% identity with Slc18a1/VMAT1
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
N449/73
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Slc18a1/VMAT1 or Slc18a3/VAChT
Research Areas
Transporters
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
VMAT2
Official Name
SLC18A2
Full Name
VMAT2
Alternative Names
SLC18A2; SVAT; SVMT; VAT2; VMAT2; solute carrier family 18 member A2; Vesicular monoamine transporter 2; PKDYS2
Uniprot ID
Q66L40
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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