Mouse Anti-GFAP Monoclonal Antibody (CBP6630)

Description

Glial fibrillary acidic protein (GFAP) in astrocytes, Bergman's glia, certain other glia in the central nervous system, satellite cells of peripheral ganglia, and non-myelinated Schwanns of peripheral nerves Strongly and specifically expressed in cells. GFAP expression is also observed in developing neural stem cells, and GFAP levels may be greatly increased in CNS damaged or diseased areas. The formation of GFAP-rich "glial scars" after CNS injury may be one of the reasons for the relatively inefficient reconnection and severing process in adults. Point mutations in the GFAP gene are the cause of Alexander disease (5). All forms of Alexander disease are characterized by the presence of Rosenthal fibers, which are cytoplasmic inclusions of GFAP found in astrocytes. Some recent interest has focused on GFAP as a protein released into the blood and cerebrospinal fluid after traumatic brain injury, stroke, and other central nervous system damage (6,7). Measurements of blood or CSF GFAP levels can provide information about the patient's performance, progress, response to treatment, or results.

Immunogen

Purified porcine spinal cord GFAP

Species Reactivity

Human; Rat; Mouse; Cow; Porcine; Horse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6630

Applications

WB; IF; IHC

Application Notes

WB: 1:5000
IF/ICC or IHC: 1:1000

Form

Liquid

Formulation

PBS, 50% glycerol

Preservatives

5mM NaN3

Concentration

1 mg/ml

Shipping

Gel Pack

Storage

Store at 4°C for short term, for longer term at -20°C

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

GFAP

Official Name

GFAP

Full Name

Glial Fibrillary Acidic Protein

Alternative Names

Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD;

Gene ID

2670(Human); 14580(Mouse); 24387(Rat)

Uniprot ID

P14136(Human); P03995(Mouse); P47819(Rat)