Mouse Anti- Monoclonal Antibody (CBP6683)
[CAT#: NAB2007FY1544]
Mouse Monoclonal to Ki67 proteins
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IF
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The Ki67 protein was first discovered when trying to generate cancer-specific monoclonal antibodies (1). Monoclonal antibodies were produced that bind to structures in the nucleus of cells that divide but do not bind to resting cells, and were shown to bind to two very large proteins with molecular weights of 345kDa and 395kDa, respectively. These two proteins are derived from alternative transcripts of a single gene. The presence of Ki67 protein (detected with appropriate antibodies) is an indicator of cell proliferation, and Ki67 expression level is one of the most reliable biomarkers of cancer cell proliferation status (2-7).
Immunogen
The recombinant construct contains the second, third, and fourth Ki67 repeats of the human sequence (amino acids 1,111-1,490) expressed and purified in E. coli.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP6683
Applications
WB; IF
Application Notes
WB: 1:1000-5000
IF 1:2000-5000
IF 1:2000-5000
Product Properties
Form
Liquid
Formulation
50% PBS, 50% glycerol
Preservatives
5mM NaN3
Concentration
1 mg/ml
Shipping
Gel Pack
Storage
Stable at 4°C for one year, for longer term store at -20°C
Handling Advice
The antibody solution should be gently mixed before use.
Research Use Only
For research use only
Target
Publications
Publications (0)
Neural Antibodies
Kits
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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