Mouse Anti-SLC6A3 Monoclonal Antibody (CBP6806)

Description

Synaptic signaling is the communication between cells that occurs at the synaptic level. Cells communicate with each other through direct contact (near secretory signals), short distances (paracrine signals), or long distances and scales (endocrine signals). Other cells form gap junctions, connecting their cytoplasm to The cytoplasm of adjacent cells. When the sending neuron is activated, the electrical impulse will propagate with it Axon. Once the impulse reaches the synapse, it triggers the release of neurotransmitters. This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]

Epitope

Binds to an located within the peptide sequence ELPWIHCNNSWNSPN

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6806

Applications

IHC

Application Notes

IHC: 1:200-1:500

Research Areas

Neurotransmitter

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

Dopamine Transporter

Official Name

SLC6A3

Full Name

Solute Carrier Family 6 Member 3

Alternative Names

Solute Carrier Family 6 Member 3; Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3; Solute Carrier Family 6 (Neurotransmitter Transporter), Member 3; Dopamine Transporter 1; DA Transporter; DAT1

Gene ID

6531(Human); 13162(Mouse); 24898(Rat)

Uniprot ID

Q01959(Human); Q61327(Mouse); P23977(Rat)