Anti-RELN Monoclonal Antibody (CBP7957)

Product Overview

Description

The antibody is a mouse monoclonal antibody raised against RELN. It has been selected for its ability to recognize RELN in immunohistochemical staining and western blotting.

Immunogen

Recombinant Reelin (RELN)

Species Reactivity

Human; Human

Clonality

Monoclonal

Isotype

IgG2b Kappa

Clone Number

CBP7957

Applications

WB; IHC; ICC; IP

Application Notes

Western blotting: 0.5-2µg/mL; Immunohistochemistry: 5-20µg/mL; Immunocytochemistry: 5-20µg/mL; Optimal working dilutions must be determined by end user.

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Concentration

1mg/mL

Purification

Protein A + Protein G affinity chromatography

Shipping

Refrigerated packaging

Storage

For long term storage, the product should be stored at -20°C or lower.

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Reelin

Official Name

RELN

Full Name

Reelin

Alternative Names

Reelin (RELN) [5] is a secreted large extracellular matrix glycoprotein that can help regulate neuronal migration and localization in the developing brain by controlling cell-cell interactions. In addition to playing an important role in early development; Reelin also continues to play a role in the adult brain. [6] It regulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. [7] [8] It also stimulates the development of dendrites [9] and dendritic spines [10] and regulates the continued migration of neuroblasts produced in adult neurogenesis sites (such as the subventricular and subgranular regions). It is found not only in the brain; but also in the liver; thyroid; adrenal glands; fallopian tubes; and breasts; and is also low in a range of anatomical regions. [11]