NeuroMab™ Mouse Anti-Reelin Monoclonal Antibody (CBP5066)

Product Overview

Immunogen

3239-3460 (h)

Species Reactivity

Mouse; Rat; Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

mouse IgG2a κ

Clone Number

CBP5066

Applications

WB; IP; IF; IHC-P; ELISA

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2786

Product Properties

Purity

>95% by HPLC

Endotoxin Level

Low Endotoxin

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Reelin

Official Name

RELN

Full Name

Reelin

Alternative Names

Reelin (RELN) [5] is a secreted large extracellular matrix glycoprotein that can help regulate neuronal migration and localization in the developing brain by controlling cell-cell interactions. In addition to playing an important role in early development; Reelin also continues to play a role in the adult brain. [6] It regulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. [7] [8] It also stimulates the development of dendrites [9] and dendritic spines [10] and regulates the continued migration of neuroblasts produced in adult neurogenesis sites (such as the subventricular and subgranular regions). It is found not only in the brain; but also in the liver; thyroid; adrenal glands; fallopian tubes; and breasts; and is also low in a range of anatomical regions. [11]