NeuroMab™ Anti-PSD-95 MAGUK scaffold protein, Clone K28/43 (CBP8456)

Product Overview

Immunogen

Fusion protein amino acids 77-299 (PDZ domains 1 and 2) of human PSD-95 (also known as Postsynaptic density protein 95, Disks large homolog 4, Synapse-associated protein 90, DLG4, Dlgh4 and SAP-90, accession number P78352)
Rat: 100% identity (223/223 amino acids identical)
Mouse: 99% identity (221/223 amino acids identical)
65-80% identity with DLG1/SAP97,
DLG2/Chapsyn-110 and DLG3/SAP102

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

CBP8456

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with DLG1/SAP97, DLG2/Chapsyn-110 or DLG3/SAP102

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

PSD 95

Official Name

DLG4

Full Name

PSD-95

Alternative Names

DLG4; PSD95; SAP-90; SAP90; Dlgh4; PSD-95; SAP90A; discs large homolog 4; discs large MAGUK scaffold protein 4; MRD62

Uniprot ID

P78352

Product Pictures

IEM

Fig. 1 Electron micrograph of K28/43 hippocampal labelling using a post-embedding immunogold method. Immunoparticles (arrows) are seen in the postsynaptic densities of dendritic spines (s) forming asymmetrical synapses with axon terminals (b).

Fig. 2 Immunoblot against adult rat brain membranes (RBM) and adult mouse hippocampal membranes (MHM) from PSD-95 and -93 knockout (KO) mice probed with K28/43 (left) or K28/86 (right) TC supe.

Fig. 3 Immunofluorescence staining of cultured rat hippocampal neurons with K28/43 (green) and K57/1 (red, Kv4.2), right image is higher magnification of left image (dotted lines).