NeuroMab™ Anti-BKBeta3a potassium channel subunit BBB Shuttle Antibody, Clone N40B/18

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNMB3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-49 (unique N-terminus) of mouse BKBeta3a (accession number XP_989315)
Human: 86% identity (42/49 amino acids identical)
Rat: not in database

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N40B/18

Applications

WB; IHC; IP; ICC

Application Notes

No cross-reactivity against BKBeta1, BKBeta2, BKBeta3b or BKBeta4

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNMB3

Official Name

KCNMB3

Full Name

BKbeta3a K+ channel

Alternative Names

Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3; Potassium Large Conductance Calcium-Activated Channel; Subfamily M Beta Member 3; Calcium-Activated Potassium Channel; Subfamily M Subunit Beta-3; Potassium Channel Subfamily M Regulatory Beta Subunit 3; Charybdotoxin Receptor Subunit Beta-3; Big Potassium Channel Beta Subunit 3; Maxi K Channel Subunit Beta-3; MaxiK Channel Beta-Subunit 3; BK Channel Beta Subunit 3; BK Channel Subunit Beta-3; K(VCA)BETA-3;