NeuroMab™ Anti-GABA-A-R-Alpha5 BBB Shuttle Antibody, Clone N415/24

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA A Receptor Alpha 5 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA-A-R-Alpha5 (also known as Gamma-aminobutyric acid receptor subunit alpha5, GABA(A) receptor subunit alpha-5 and Gabra5, accession number P31644)
Mouse: 78% identity (41/52 amino acids identical)
Rat: 73% identity (39/53 amino acids identical)
<50% identity with GABA-A-R-Alpha2 and other GABA-A receptors

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N415/24

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with GABA-A-R-Alpha2 (or other GABAA receptors based on KO validation data)

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABA A Receptor Alpha 5

Official Name

GABRA5

Full Name

GABA(A)R, Alpha5

Alternative Names

GABRA5; gamma-aminobutyric acid type A receptor alpha5 subunit; EIEE79; gamma-aminobutyric acid type A receptor subunit alpha5

Uniprot ID

P31644

Product Pictures

Fig. 1 Immunoblot against crude low-speed pellet fractions from adult rat brain (RBLSP) and wild-type (WT) and GABA-A-RAlpha5 knockout (KO) mouse brains probed with N415/24 (left) and N52A/42 (right) TC supe.

Publications