NeuroMab™ Anti-Lingo1 Antibody(NRP-0422-P1646)

Product Overview

Description

The antibody promotes oligodendrocyte survival and myelination in vivo; protected DRG neurons from myelin-mediated inhibition of neurite outgrowth; promotes myelination in vitro.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; IHC; FC; IP; In Vitro; In Vivo

Relevant Diseases

Multiple Sclerosis

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Lingo1

Official Name

LINGO1

Full Name

Leucine rich repeat and Immunoglobin-like domain-containing protein 1

Alternative Names

LINGO1; LERN1; LRRN6A; UNQ201; leucine rich repeat and Ig domain containing 1; MRT64

Gene ID

84894(Human); 235402(Mouse); 315691(Rat)

Uniprot ID

Q96FE5(Human); Q9D1T0(Mouse)

Product Pictures

FuncS

Figure 1: A: CC1 antibody staining of mouse oligodendrocytes in the cuprizone model. B. Anti-MBP protein antibody or luxol fast blue staining of cuprizone model mouse neurons. C: Quantification of CC1 antibody-positive oligodendrocytes at weeks 4 and 6.

Publications