NeuroMab™ Anti-Sp35 BBB Shuttle Antibody(NRZP-1022-ZP3037)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; IHC; FC; IP; In Vitro; In Vivo

Relevant Diseases

Pain

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Lingo1

Official Name

LINGO1

Full Name

Leucine rich repeat and Immunoglobin-like domain-containing protein 1

Alternative Names

LINGO1; LERN1; LRRN6A; UNQ201; leucine rich repeat and Ig domain containing 1; MRT64

Product Pictures

FuncS

Figure 1: A: CC1 antibody staining of mouse oligodendrocytes in the cuprizone model. B. Anti-MBP protein antibody or luxol fast blue staining of cuprizone model mouse neurons. C: Quantification of CC1 antibody-positive oligodendrocytes at weeks 4 and 6.

Publications