Mouse Anti-TH Monoclonal Antibody (CBP6804)

Description

Synaptic signaling is the communication between cells that occurs at the synaptic level. Cells communicate with each other through direct contact (near secretory signals), short distances (paracrine signals), or long distances and scales (endocrine signals). Other cells form gap junctions, connecting their cytoplasm to The cytoplasm of adjacent cells. When the sending neuron is activated, the electrical impulse will propagate with it Axon. Once the impulse reaches the synapse, it triggers the release of neurotransmitters. Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It uses molecular oxygen (O2) as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor of dopamine, which is also a precursor of the important neurotransmitters norepinephrine (norepinephrine) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate-limiting step in the synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene, and this enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons, and adrenal medulla. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together form the family of aromatic amino acid hydroxylases (AAAHs).

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6804

Applications

IHC

Application Notes

IHC: 1:500-1:1000

Research Areas

Neurotransmitter

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

Tyrosine Hydroxylase

Official Name

TH

Full Name

Tyrosine hydroxylase

Alternative Names

TH; Th; DYT14; DYT5b; TYH; tyrosine hydroxylase; Tyrosine hydroxylase

Gene ID

7054(Human); 21823(Mouse); 25085(Rat)

Uniprot ID

P07101(Human); P24529(Mouse); P04177(Rat)