AAV2/9-mCaMKIIa-mCherry-P2A-TetTox-WPRE-pA [Synaptic Inhibition]

[CAT#: NTA-2012-ZP271]

Tracer Type:: Neuronal Synaptic Depression

Applications:: Synaptic Inhibition

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Product Overview

Description

TetTox, also known as TeNT, is the light chain of Tetanus toxin. It is a protease that can specifically degrade VAMP2, inhibit the release of synaptic glutamate transmitter vesicles, and interrupt the transmission of nerve electrical signals.

The mCaMKIIa promoter, cloned from the promoter region of mouse calmodulin-dependent protein kinase IIa, is 1.3 kb in length, and is specifically expressed in excitatory neuronal cells.