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Creative Biolabs
Product

NeuroMab™ Anti-GABABR1 GABA-B receptor BBB Shuttle Antibody, Clone N93A/49

[CAT#: NRZP-0423-ZP124]

Species Reactivity:
Rat; Mouse; Human
Applications:
WB; IHC; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA B Receptor 1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1 (also known as Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1 and Gb1, accession number Q9Z0U4)
Mouse: 98% identity (103/105 amino acids identical)
Human: 97% identity (102/105 amino acids identical)
100% identity between A, B and C isoforms
<30% identity with GABABR2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N93A/49

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with GABABR2

Conjugation

Unconjugated
Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.
Target

Target

GABA B Receptor 1

Official Name

GABBR1

Full Name

GABA(B)R1

Alternative Names

GABBR1; GABABR1; GABBR1-3; GB1; GPRC3A; dJ271M21.1.1; dJ271M21.1.2; gamma-aminobutyric acid type B receptor subunit 1

Uniprot ID

Q9Z0U4
Product Pictures
IB

Fig. 1 Immunoblot versus crude membranes made from adult rat brain (RBM) or GABABR1 wild-type (WT) or knockout (KO) mice probed with N93A/49 (left) or K89/34 (right) TC supe.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

IHC

Fig. 3 Adult rat brain immunohistochemistry.

IB

Fig. 4 Adult rat brain membrane immunoblot.

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