Product
NeuroMab™ Anti-GluA1/GluR1 glutamate receptor BBB Shuttle Antibody, Clone N355/1
[CAT#: NRZP-0423-ZP144]
- Species Reactivity:
- Rat; Mouse
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GluA1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1 (also known as Glutamate receptor 1, Ionotropic AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, GLUH1 and Gria1, accession number P19490)
Mouse: 99% identity (388/389 amino acids identical)
Human: 97% identity (379/389 amino acids identical)
100% identity between Flip and Flop isoforms
>50% identity with GluA2/GluR2, GluA3/GluR3 and GluA4/GluR4
Mouse: 99% identity (388/389 amino acids identical)
Human: 97% identity (379/389 amino acids identical)
100% identity between Flip and Flop isoforms
>50% identity with GluA2/GluR2, GluA3/GluR3 and GluA4/GluR4
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N355/1
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with GluR2
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GluA1
Official Name
GRIA1
Full Name
GluA1/GluR1 glutamate receptor
Alternative Names
GRIA1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; glutamate ionotropic receptor AMPA type subunit 1; Glutamate receptor; ionotropic; AMPA 1
Uniprot ID
P19490
Product Pictures
IF
Fig. 1 Immunofluorescence staining of 14 DIV cultured rat cortical neuron with N355/1.
IB
Fig. 2 Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged GluR1, GluR2 or Kv2.1 plasmid and probed with N355/1 (left), L21/32 (middle) or N52A/42 (right) TC supe.
IHC
Fig. 3 Adult rat hippocampus immunohistochemistry.
IB
Fig. 4 Adult rat brain membrane immunoblot.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
