NeuroMab™ Anti-GluA1/GluR1 glutamate receptor BBB Shuttle Antibody, Clone N355/1

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GluA1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1 (also known as Glutamate receptor 1, Ionotropic AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, GLUH1 and Gria1, accession number P19490)
Mouse: 99% identity (388/389 amino acids identical)
Human: 97% identity (379/389 amino acids identical)
100% identity between Flip and Flop isoforms
>50% identity with GluA2/GluR2, GluA3/GluR3 and GluA4/GluR4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N355/1

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with GluR2

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GluA1

Official Name

GRIA1

Full Name

GluA1/GluR1 glutamate receptor

Alternative Names

GRIA1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; glutamate ionotropic receptor AMPA type subunit 1; Glutamate receptor; ionotropic; AMPA 1

Uniprot ID

P19490

Product Pictures

Fig. 1 Immunofluorescence staining of 14 DIV cultured rat cortical neuron with N355/1.

Fig. 2 Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged GluR1, GluR2 or Kv2.1 plasmid and probed with N355/1 (left), L21/32 (middle) or N52A/42 (right) TC supe.