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Creative Biolabs

NeuroMab™ Anti-KCC2 transporter BBB Shuttle Antibody, Clone N1/12

[CAT#: NRZP-0423-ZP183]

Species Reactivity:
Human; Rat; Mouse
Applications:
WB; IHC; IP; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCC2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2b (also known as Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, K-Cl cotransporter 2, Neuronal K-Cl cotransporter, Furosemide-sensitive K-Cl cotransporter and Erythroid K-Cl cotransporter 2, accession number NP_599190)
Human: 96% identity (108/112 residues identical)
Mouse: 95% identity (107/112 residues identical)
100% identity with KCC2a
<40% identity with KCC1, KCC3, KCC4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N1/12

Applications

WB; IHC; IP; ICC

Application Notes

Does not react with KCC1, KCC3 or KCC4

Research Areas

Transporters

Conjugation

Unconjugated
Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.
Target

Target

KCC2

Official Name

SLC12A5

Full Name

KCC2

Alternative Names

SLC12A5; KCC2; Chloride potassium symporter 5; EIEE34; EIG14; hKCC2; solute carrier family 12 member 5

Uniprot ID

NP_599190
Product Pictures
IHC

Fig. 1 Adult rat cerebellum immunohistochemistry.

IHC

Fig. 2 Adult hippocampus immunohistochemistry.

IB

Fig. 3 Adult rat brain membrane immunoblot.

Publications

Publications (0)

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