NeuroMab™ Anti-KCC2 transporter BBB Shuttle Antibody, Clone N1/12
[CAT#: NRZP-0423-ZP183]
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- WB; IHC; IP; ICC
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCC2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2b (also known as Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, K-Cl cotransporter 2, Neuronal K-Cl cotransporter, Furosemide-sensitive K-Cl cotransporter and Erythroid K-Cl cotransporter 2, accession number NP_599190)
Human: 96% identity (108/112 residues identical)
Mouse: 95% identity (107/112 residues identical)
100% identity with KCC2a
<40% identity with KCC1, KCC3, KCC4
Human: 96% identity (108/112 residues identical)
Mouse: 95% identity (107/112 residues identical)
100% identity with KCC2a
<40% identity with KCC1, KCC3, KCC4
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N1/12
Applications
WB; IHC; IP; ICC
Application Notes
Does not react with KCC1, KCC3 or KCC4
Research Areas
Transporters
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCC2
Official Name
SLC12A5
Full Name
KCC2
Alternative Names
SLC12A5; KCC2; Chloride potassium symporter 5; EIEE34; EIG14; hKCC2; solute carrier family 12 member 5
Uniprot ID
NP_599190
Product Pictures
IHC
Fig. 1 Adult rat cerebellum immunohistochemistry.
IHC
Fig. 2 Adult hippocampus immunohistochemistry.
IB
Fig. 3 Adult rat brain membrane immunoblot.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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