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Creative Biolabs

Mouse Anti-Rat KCC2 Monoclonal Antibody (CBP3998)

[CAT#: NAB20121006LS]

Anti-KCC2 Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Rat
Applications:
WB; IHC-P

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Product Overview

Description

Potassium-chloride cotransporter member 5 (also known as KCC2 and SCL12A5) is responsible for establishing the chloride ion gradient in neurons through the maintenance of low intracellular chloride concentrations. Mediates synaptic inhibition, protects against excitotoxicity and modulates plasticity.

Immunogen

This monoclonal antibody was raised against a fusion protein corresponding to amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2b.

Species Reactivity

Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP3998

Applications

WB; IHC-P

Application Notes

WB (10.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

KCC2

Official Name

SLC12A5

Full Name

Potassium-chloride transporter member 5

Alternative Names

SLC12A5; KCC2; Chloride potassium symporter 5; EIEE34; EIG14; hKCC2; solute carrier family 12 member 5

Gene ID

57468(Human); 57138(Mouse); 171373(Rat)

Uniprot ID

Q9H2X9(Human); Q91V14(Mouse); Q63633(Rat)
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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