Product
NeuroMab™ Anti-KCNQ4 potassium channel BBB Shuttle Antibody, Clone N43/6
[CAT#: NRZP-0423-ZP232]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; IP; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNQ4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 2-77 of human KCNQ4 (Kv7.4, KvLQT4, accession number P56696)
Mouse: 94% identity (71/75 amino acids identical)
Rat: 94% identity (71/75 amino acids identical)
Mouse: 94% identity (71/75 amino acids identical)
Rat: 94% identity (71/75 amino acids identical)
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N43/6
Applications
WB; IHC; IP; ICC
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCNQ4
Official Name
KCNQ4
Full Name
Kv7.4/KCNQ4 K+ channel
Alternative Names
KCNQ4; DFNA2; DFNA2A; KV7.4; potassium voltage-gated channel subfamily Q member 4
Uniprot ID
P56696
Product Pictures
IB
Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM (left lane) and COS-1 cells transiently transfected with KCNQ4 (middle lane) or Kv2.1 (right lane) plasmids and probed with pure N43/6 (left panel) or K89/41 TC supe (right panel).
IF
Fig. 2 Transfected cell immunofluorescence: COS-1 cell expressing KCNQ4 in a field of untransfected cells. Red=N43/6, Blue=Hoechst nuclear stain.
IF
Fig. 3 Mouse crista ampullaris immunofluorescence. Red=N43/6, Blue= oechst nuclear stain.
IF
Fig. 4 Mouse outer hair cells in organ of Corti immunofluorescence. Red=N43/6, Blue=Hoechst nuclear stain.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
