NeuroMab™ Anti-NgR BBB Shuttle Antibody(NRZP-1022-ZP3039)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; WB; Inhib; Block; In Vitro; Neut

Relevant Diseases

Alzheimer's Disease; Parkinson's Disease; Multiple Sclerosis; Amyotrophic Lateral Sclerosis

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Nogo

Official Name

RTN4R

Full Name

Reticulon 4 receptor

Alternative Names

RTN4R; NGR; NOGOR; Reticulon 4 receptor

Product Pictures

ELISA

Figure 1: Antibodies mAb50 and mAb51 binding to rat NgR.

ELISA

Figure 2: AP-Nogo66 competes for binding with mAb50 and mAb51 of NgR-Fc.

ELISA

Figure 3: Nogo66 competes with mAB50 and mAB51 for binding to human and rat NgR expressed on HEK293f cells.

ELISA

Figure 4: Binding of mAB50 and mAB51 to NTera 2 cells.

FuncS

Figure 5: Quantification of neurite outgrowth of NTera 2 cell aggregates.

FuncS

Figure 6: Deletion mutants of hNgR.

FuncS

Figure 7: Competition of MAG-Fc binding to NgR-Fc.

FuncS

Figure 8: Rat dorsal root ganglion neurons under permissive and inhibitory conditions and neutralization of Nogo66-induced inhibition of neurite outgrowth by mAb50.