NeuroMab™ anti-TfR1 VNAR BBB Shuttle antibody(NRZP-1022-ZP4064)
[CAT#: NRZP-1022-ZP4064]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- In Vitro
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
In Vitro
Relevant Diseases
Tumor
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
TransferrinReceptor
Official Name
TfR
Full Name
Transferrin Receptor
Alternative Names
CD71; TFR1
Product Pictures
FuncS
Figure 1 TXB2 VNAR analysis
FuncS
Figure 2 In vivo study of TXB2 in AβPP transgenic mice.
FuncS
Figure 3. In vivo functional activity of TXB2 variants correlates with in vitro TfR1 binding.
IHC
Figure 4 IHC assessment of TXB4 shuttling brain penetration.
FuncS
Figure 5 Brain-specific biodistribution of TXB4 and pharmacodynamic activity of TXB4 fused to NT.
FuncS
Figure 6 TXB4 is highly effective in delivering therapeutic antibodies to the brain.
IHC
Figure 7 IHC assessment of antibody delivery to the brain parenchyma using the TXB4 shuttle.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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