NeuroMab™ Anti-TNFα BBB Shuttle Antibody(NRZP-1022-ZP2705)
[CAT#: NRZP-1022-ZP2705]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; Cyt; In Vitro; In Vivo
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
ELISA; Cyt; In Vitro; In Vivo
Relevant Diseases
Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
TNFα
Official Name
TNF-α
Full Name
TNF-alpha
Alternative Names
TNF; DIF; TNF-alpha; TNFA; TNFSF2; Tumour necrosis factor; TNF-α; tumor necrosis factor; TNLG1F; Tumor necrosis factor alpha
Product Pictures
Cyt
Figure 1 shows the effect of anti-TNF monoclonal antibodies 1 and 32 on TNF cytotoxicity in WEHI-164 cells.
FuncS
Figure 2 shows the potentiation of TNF regressive activity by MAb 32.
FuncS
Figure 3 shows the enhancement of TNF-induced tumor regression by MAb 32 - dose response at day 1.
FuncS
Figure 4 shows the binding of radiolabeled TNF to receptors on bovine aortic endothelial cells.
FuncS
Figure 5 shows the receptor binding study of TNF complexed with MAb 32 (—◆—), control antibody, and MAb 47 (—▪—) on the melanoma cell line MM418E.
FuncS
Figure 6 shows the effect of MAb 32 (▪) control MAb and MAb 47 (*) on TNF-mediated tumor regression in vivo.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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