NeuroMab™ Anti-TNFα BBB Shuttle Antibody(NRZP-1022-ZP2705)
[CAT#: NRZP-1022-ZP2705]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; Cyt; In Vitro; In Vivo
Certificate of Analysis Lookup
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
ELISA; Cyt; In Vitro; In Vivo
Relevant Diseases
Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
TNFα
Official Name
TNF-α
Full Name
TNF-alpha
Alternative Names
TNF; DIF; TNF-alpha; TNFA; TNFSF2; Tumour necrosis factor; TNF-α; tumor necrosis factor; TNLG1F; Tumor necrosis factor alpha
Product Pictures
Cyt
Figure 1 shows the effect of anti-TNF monoclonal antibodies 1 and 32 on TNF cytotoxicity in WEHI-164 cells.
FuncS
Figure 2 shows the potentiation of TNF regressive activity by MAb 32.
FuncS
Figure 3 shows the enhancement of TNF-induced tumor regression by MAb 32 - dose response at day 1.
FuncS
Figure 4 shows the binding of radiolabeled TNF to receptors on bovine aortic endothelial cells.
FuncS
Figure 5 shows the receptor binding study of TNF complexed with MAb 32 (—◆—), control antibody, and MAb 47 (—▪—) on the melanoma cell line MM418E.
FuncS
Figure 6 shows the effect of MAb 32 (▪) control MAb and MAb 47 (*) on TNF-mediated tumor regression in vivo.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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