Mouse Anti-USP46 Monoclonal Antibody (CBP6752)

[CAT#: NAB2007FY1701]

Amyotrophic Lateral Sclerosis,
Parkinson's, Alzheimer's and Huntington's diseases

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB; IF

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Product Overview

Description

Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]

Epitope

Binds to an located within the peptide sequence TNETRCLNCE

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6752

Applications

WB; IF

Application Notes

WB: 1 µg/ml
IF: 2-10 µg/ml

Relevant Diseases

Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

USP46

Official Name

USP46

Full Name

Ubiquitin Specific Peptidase 46

Alternative Names

Ubiquitin Specific Peptidase 46; Ubiquitin-Specific-Processing Protease 46; Ubiquitin Specific Protease 46; Deubiquitinating Enzyme 46; Ubiquitin Thioesterase 46; EC 3.4.19.12; EC 3.1.2.15