NeuroMab™ Anti-CALB1/calbindin BBB Shuttle Antibody, Clone L109/39

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Calbindin BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-261 (full-length) of human CALB1 (also known as Calbindin D28, Vitamin D-dependent calcium-binding protein, D-28K, Spot 35 protein, CAB27 and PCD-29, accession number P05937)
Rat: 98% identity (257/261 amino acids identical)
Mouse: 98% identity (257/261 amino acids identical)
<60% identity with CALB2/Calretinin

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

L109/39

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Calbindin

Official Name

CALB1

Full Name

Calbindin

Alternative Names

CALB

Uniprot ID

P05937

Product Pictures

IHC

Fig. 1 Adult rat hippocampus immunohistochemistry.

Fig. 2 Array tomography immunofluorescence of Lowicrylembedded sections from adult mouse cerebellum with L109/39 (red) and DAPI (blue). Left panel is a single 70 nm section imaged with a 20X objective, with a scale bar of 50 µm. Right panel is a MAX projection of 7 serial 70 nm sections imaged with a 63X objective, with a scale bar of 20 µm.