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Creative Biolabs

NeuroMab™ Anti-FGFR1 BBB Shuttle Antibody(NRZP-1022-ZP3895)

[CAT#: NRZP-1022-ZP3895]

Host Species:
Rat
Species Reactivity:
Human
Applications:
WB; ELISA; In Vitro; In Vivo; ADCC; Antagonist

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rat

Applications

WB; ELISA; In Vitro; In Vivo; ADCC; Antagonist

Relevant Diseases

Multiple Sclerosis; Glioma
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

FGFR1

Official Name

FGFR1

Full Name

Fibroblast Growth Factor Receptor 1

Alternative Names

Fibroblast Growth Factor Receptor 1; Basic Fibroblast Growth Factor Receptor 1; Fms-Related Tyrosine Kinase 2; Proto-Oncogene C-Fgr; EC 2.7.10.1; BFGF-R-1; FGFR-1; N-SAM; BFGFR; FGFBR; FLT-2; HBGFR; FLT2; CEK; FLG;
Product Pictures

Figure 1A depicts the binding sensorgrams of mAb #A08 and buffer to FGFR1-IIIb and -IIIc, FGFR2 and FGFR3 The binding signal (response units, RU) is plotted over time. Buffer control and mAb #A08 were tested for binding to huFGFR1b-IIIb, -IIIc, huFGFR2 and huFGFR3.

Figure 1B depicts the binding sensorgrams of mAb #A08 and buffer to FGFR1-IIIb and -IIIc, FGFR2 and FGFR3 The binding signal (response units, RU) is plotted over time. Buffer control and mAb #A08 were tested for binding to huFGFR1b-IIIb, -IIIc, huFGFR2 and huFGFR3.

ELISA

Figure 2 shows the mapping of mAb #A08, mAb #A05, and a control antibody (anti-egg lysozyme) to the domain of lg-D2 by ELISA. The optical density measured at 450 nm was plotted against antibody concentration (using the Logio scale).

ELISA

Figure 3A shows the binding of various affinity matured mAbs to human FGFRI b (1Mb) (hFGFRI b-IIIb) and human FGFRI b (IIIc) (hFGFRI b-IIIc) measured by ELISA.

A) mAbs are in lgG1 format,

ELISA

Figure 3B shows the binding of various affinity matured mAbs to human FGFRI b (1Mb) (hFGFRI b-IIIb) and human FGFRI b (IIIc) (hFGFRI b-IIIc) measured by ELISA.

B) mAbs are in monovalent SEEDbody format.

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