Mouse Anti-FGFR1 Monoclonal Antibody (CBP2667)

Product Overview

Description

Fibroblast growth factor receptor 1 (FGFR1) is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors. FGFR1 has been implicated in diverse biological processed including embryonic development, cell proliferation, differentiation, migration, and tumorigenesis. Mutations in FGFR1 gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, squamous cell lung cancer and autosomal dominant Kallmann syndrome. Alternatively spliced variants which encode different protein isoforms have been described.

Expression Host

Mammalian cells

Immunogen

FGFR1 fusion protein Ag3646

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2c

Clone Number

CBP2667

Applications

FC; IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Growth and Development

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1120 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

FGFR1

Official Name

FGFR1

Full Name

Fibroblast growth factor receptor 1

Alternative Names

bFGF R 1; BFGFR; CD331; CEK; FGFBR; FGFR 1; FGFR1; FLG; FLT 2; FLT2; Fms like tyrosine kinase 2; HBGFR; KAL2

Gene ID

2260(Human)

Uniprot ID

P11362(Human)

References

1. Zhou, P. T., Wang, L. P., Qu, M. J., Shen, H., Zheng, H. R., Deng, L. D.,... & Tian, H. L. (2019). Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats. CNS Neuroscience & Therapeutics, 25(6), 748-758. 2. Zhang, L., Liu, Y., Huang, Z., Nan, L., Wang, F., Zhou, S.,... & Feng, X. (2019). Toxicity effects of methylene blue on rat intervertebral disc annulus fibrosus cells. Pain physician, 22, 155-164. 3. Yu, B., Zhong, F. M., Yao, Y., Deng, S. Q., Xu, H. Q., Lu, J. F.,... & Shen, X. C. (2019). Synergistic protection of tetramethylpyrazine phosphate and borneol on brain microvascular endothelium cells injured by hypoxia. American journal of translational research, 11(4), 2168.

Publications