NeuroMab™ Anti-GABA-A-R-Beta3 BBB Shuttle Antibody, Clone N87/25
[CAT#: NRZP-0423-ZP116]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABRB3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta-3, accession number P63080)
Rat: 100% identity (64/64 amino acids identical)
Human: 85% identity (53/64 amino acids identical)
<40% identity with GABA-A-R-Beta1 or -Beta2
Rat: 100% identity (64/64 amino acids identical)
Human: 85% identity (53/64 amino acids identical)
<40% identity with GABA-A-R-Beta1 or -Beta2
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N87/25
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with GABA-A-R-Beta1 or -2
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GABRB3
Official Name
GABRB3
Full Name
GABA(A)R, Beta3
Alternative Names
GABRB3; ECA5; gamma-aminobutyric acid type A receptor beta3 subunit; EIEE43; gamma-aminobutyric acid type A receptor subunit beta3
Uniprot ID
P63080
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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