NeuroMab™ Anti-GABA-A-R-Beta3 BBB Shuttle Antibody, Clone N87/25

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABRB3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta-3, accession number P63080)
Rat: 100% identity (64/64 amino acids identical)
Human: 85% identity (53/64 amino acids identical)
<40% identity with GABA-A-R-Beta1 or -Beta2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N87/25

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with GABA-A-R-Beta1 or -2

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABRB3

Official Name

GABRB3

Full Name

GABA(A)R, Beta3

Alternative Names

GABRB3; ECA5; gamma-aminobutyric acid type A receptor beta3 subunit; EIEE43; gamma-aminobutyric acid type A receptor subunit beta3

Uniprot ID

P63080

Product Pictures

Fig. 1 Immunofluorescence of cultured hippocampal neurons with N87/25 (red) and GABA-A-R-Gamma2 rabbit polyclonal (green).

Fig. 2 Immunoblot against membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N87/25 (left) or N52A/42 (right) TC supe.