NeuroMab™ Anti-GABA-A-R-Epsilon BBB Shuttle Antibody, Clone N413/67

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABRE BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 27-253 (extracellular N-terminus) of human GABA-A receptor Epsilon (also known as Gamma-aminobutyric acid receptor subunit epsilon and GABRE, accession number P78334)
Rat: 75% identity (171/228 amino acids identical)
Mouse: 76% identity (163/214 amino acids identical)
<50% identity with other GABA-A receptors

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N413/67

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABRE

Official Name

GABRE

Full Name

GABA(A)R, Epsilon

Alternative Names

Gamma-Aminobutyric Acid Type A Receptor Epsilon Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor; Epsilon; GABA(A) Receptor Subunit Epsilon; GABA(A) Receptor; Epsilon;

Uniprot ID

P78334

Product Pictures

Fig. 1 Immunoblot against crude membranes and lowspeed pellets from adult rat heart (RHM, RHLSP) and brain (RBM, RBLSP) and extracts of COS cells transiently transfected with HA-tagged GABAAREpsilon or untagged Kv2.1 plasmid probed with N413/67 (left) or N52A/42 (right) TC supe.