NeuroMab™ Anti-HCN2 cyclic nucleotide-gated channel BBB Shuttle Antibody, Clone N71/37

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HCN2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 761-863 (cytoplasmic C-terminus) of rat HCN2 (also known as potassium /sodium hyperpolarization-activated cyclic nucleotide gated channel 2, accession number Q9JKA9)
Mouse: 98% identity (101/103 amino acids identical)
Human: 82% identity (86/104 amino acids identical)
<50% identity with HCN1, HCN3 and HCN4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Applications

WB; IHC; IP; ICC

Application Notes

No cross-reactivity against HCN1

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

HCN2

Official Name

HCN2

Alternative Names

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium And Sodium Channel 2; Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2; Brain Cyclic Nucleotide-Gated Channel 2; BCNG-2; BCNG2; Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2; HAC-1;

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and of COS-1 cells transfected with GFPHCN1, GFP-HCN2 or Kv2.1 plasmids and probed with N71/37 (left), K89/34 (middle) or a control (right) TC supe.

Fig. 2 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].