NeuroMab™ Anti-Collybistin BBB Shuttle Antibody, Clone L120/12

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HCN2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 105-455 of rat Collybistin (also known as Rho guanine nucleotide exchange factor 9, Rac/Cdc42 guanine nucleotide exchange factor 9, PEM-2 homolog, ARHDH9, Arhgef9 and Kiaa0424, accession number Q9QX73)
Mouse: 99% identity (350/351 amino acids identical)
Human: 99% identity (348/351 amino acids identical)
>65% identity with Spata13 and ARHGEF4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

L120/12

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

HCN2

Official Name

HCN2

Full Name

Collybistin

Alternative Names

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium And Sodium Channel 2; Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2; Brain Cyclic Nucleotide-Gated Channel 2; BCNG-2; BCNG2; Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2; HAC-1;

Uniprot ID

Q9QX73

Product Pictures

Fig. 1 Array tomography immunofluorescence of a Lowicryl-embedded 70 nm section from adult mouse cortex with L120/12 (green), rabbit mAb GAD2 (Cell Signaling #5843, magenta) and DAPI (blue). The insert shows three consecutive sections through the synapse that is marked with a white box.