NeuroMab™ Anti-SORT1 BBB Shuttle Antibody(NRZP-1022-ZP3961)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

In Vitro; In Vivo; Block

Relevant Diseases

Parkinson's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

SORT1

Official Name

SORT1

Full Name

Sortilin

Alternative Names

SORT1; Gp95; LDLCQ6; NT3; NTR3; Sortilin 1

Product Pictures

FCM

Figure 1 depicts sortin cell surface expression on human U-251 cells.

FCM

Figure 2 depicts sortin cell surface expression on mouse N2A cells.

Figure 3 shows the level of binding of the anti-sortilin antibody S-22 to sortilin in the presence or absence of NTS.

Figure 3 depicts the measurement of sorterin levels using Western blot analysis of leukocyte lysates from mice.

FuncS

Figure 4 depicts the results of a collagen-induced arthritis study in mice. Biweekly injection of 40 mg/kg anti-Sortilin antibody S-15-6 significantly reduced clinical arthritis scores compared to controls (PBS and MOPC-21/msIgG1).

FuncS

Figure 5 depicts progranulin (PGRN) in cerebrospinal fluid (CSF) samples obtained from rats two or six days after intra-articular (ia) injection into the knee or intraperitoneal (ip) injection of anti-sortin antibody S-15 ) protein level-6 or control antibody. n=2 rats/group. **p<0.001 One-way ANOVA.

Publications