NeuroMab™ Anti-Sortilin BBB Shuttle Antibody(NRZP-1022-ZP2774)
[CAT#: NRZP-1022-ZP2774]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mammalian
- Applications:
- ELISA; Inhib; In Vitro; In Vivo; Antagonist
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human; Mammalian
Clonality
Monoclonal
Host Species
Mouse
Applications
ELISA; Inhib; In Vitro; In Vivo; Antagonist
Relevant Diseases
Alzheimer's Disease
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
SORT1
Official Name
SORT1
Full Name
Sortilin
Alternative Names
SORT1; Gp95; LDLCQ6; NT3; NTR3; Sortilin 1
Product Pictures
Inhib
Figure 1 shows the dose-dependent inhibition of biotinylated progranulin binding to soltilin-expressing cells by anti-soltilin antibodies.
Inhib
Figure 2 shows cell surface expression levels of saltylin after incubation with anti-saltillin antibody for 72 hours.
Inhib
Figure 3 shows the measurement of mouse progranulin (PGRN) protein levels in mouse plasma samples at different times after injection of anti-saultyrin antibodies.
WB
Figure 4 shows the measurement of saltyrin protein levels using western blot analysis of mouse-derived leukocyte lysates.
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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