NeuroMab™ Anti-Sortilin BBB Shuttle Antibody(NRZP-1022-ZP2773)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mammalian

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; Inhib; In Vitro; In Vivo; Antagonist

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

SORT1

Official Name

SORT1

Full Name

Sortilin

Alternative Names

SORT1; Gp95; LDLCQ6; NT3; NTR3; Sortilin 1

Product Pictures

Inhib

Figure 2 is a bar graph showing the effect of different doses of MMP-12 binding proteins M08-H09 and M11-H11 on the peribronchial inflammation score in an OVA-challenged mouse model of airway inflammation.

Inhib

Figure 3 is a bar graph showing the effect of MMP-12 binding protein (M08-H09) on the infiltration of inflammatory cells into the air sacs of carrageenan-stimulated mice.

Inhib

Figure 4 is a bar graph showing ELISA competition assays performed with four different MMP-12 binding proteins M08H09, M0013-G12, M0016-A11 and R0062-E11.